Shamrock is a city in Wheeler County, Texas, United States. As of the 2020 Census, the city had a total population of 1,789. The city is located in the eastern portion of the Texas Panhandle, centered along the crossroads of Interstate 40 and U.S. Route 83. It is 110 miles (180 km) east of Amarillo, 188 miles (303 km) west of Oklahoma City, and 291 miles (468 km) northwest of Dallas.