Cherokee County is a county located in the U.S. state of Texas. As of the 2020 census, its population was 50,412. The county seat is Rusk, which lies 130 miles southeast of Dallas and 160 miles north of Houston. The county was named for the Cherokee, who lived in the area before being expelled in 1839. Cherokee County comprises the Jacksonville micropolitan statistical area, which is also included in the Tyler–Jacksonville combined statistical area.